Preparation and properties of Pue-loaded HA-ADH-PS nanomicelles

Preparation and properties of Pue-loaded HA-ADH-PS nanomicelles

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Puerarin (Pue) is the most abundant isoflavonoid in kudzu root.It has been widely used as a therapeutic agent for the treatment of cardiovascular diseases.However, poor-bioavailability of puerarin is the main obstacle to its widespread clinical applications.In this paper, HA-ADH-PS nanomicelles were prepared by chemical modification, noncovalent modification and etc, harry potter magsafe case and characterized by means of FT-IR, ultraviolet (UV) and thermogravimetric analysis (TG).

The encapsulation efficiency and drug loading of Pue-loaded HA-ADH-PS nanomicelles were 45.1% and 19.89% by UV, respectively.It could be observed from the transmission electron microscopy (TEM) images that HA-ADH-PS micelles appeared obvious spherical structure in the water.

The particle size of HA-ADH-PS nanomicelles and Pue-loaded HA-ADH-PS nanomicelles were about 136.8 nm and 119.5 nm with a PDI of 0.237 and 0.

272, respectively.The fluorescence probe method was used to characterize the critical micelle read more concentration, the critical micelle concentration (CMC) value of the nanomicells was 0.002 g/L and the results met the requirements and ensured the stability of micelles after dilution.DPPH assay suggested that Pue-loaded HA-ADH-PS nanomicelles had an obvious radical scavenging effect in vitro.

MTT test showed that Pue-loaded HA-ADH-PS nanomicelles was non-toxic and had good biocompatibility.Thus, Pue-loaded HA-ADH-PS nanomicelles could be used as a potential drug copyright for puerarin.